Corpus ID: 70766641

Late-breaking abstract: BAFF: A self-perpetuating mechanism of B cell activation in COPD

@article{Polverino2014LatebreakingAB,
  title={Late-breaking abstract: BAFF: A self-perpetuating mechanism of B cell activation in COPD},
  author={F. Polverino and J. Pons and A. Iglesias and {\'A}. R{\'i}os and Sergio Scrimini and C. Crespi and J. Sauleda and C. Owen and B. Celli and A. Agusti and B. Cosio},
  journal={European Respiratory Journal},
  year={2014},
  volume={44},
  pages={2950}
}
Background: The adaptive immune response, including the recruitment and activation of lymphocytes, may contribute to emphysema pathogenesis. B cell Activating Factor (BAFF) promotes B cell tolerance and homeostasis, and is overexpressed in COPD lymphoid follicles. However, it is not know whether BAFF is expressed in lymphocytes in the blood or BAL compartments in COPD. Methods: 1) BAFF expression in B and T cells in bronchoalveolar lavage (BAL) and blood samples was quantified by flow cytometry… Expand
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