Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone.

@article{Itabashi1993LateAR,
  title={Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone.},
  author={Sayaka Itabashi and Takashi Ohrui and Kiyohisa Sekizawa and Tadaomi Aikawa and Hayakazu Nakazawa and Hidetada Sasaki},
  journal={International archives of allergy and immunology},
  year={1993},
  volume={101 2},
  pages={215-20}
}
To determine if late asthmatic response (LAR) is associated with hyperresponsiveness of airway smooth muscle itself, we performed antigen challenge in dogs treated with Metopirone. We studied the contractile response to acetylcholine (ACh) in isolated bronchial and bronchiolar segments 8 h after either saline inhalation (the control group) or antigen challenge in dogs demonstrating immediate asthmatic response (IAR) alone and in dogs demonstrating both IAR and LAR. Airway responses to Ascaris… CONTINUE READING