Late Adolescent Expression of GluN2B Transmission in the Prefrontal Cortex Is Input-Specific and Requires Postsynaptic Protein Kinase A and D1 Dopamine Receptor Signaling

@article{FloresBarrera2014LateAE,
  title={Late Adolescent Expression of GluN2B Transmission in the Prefrontal Cortex Is Input-Specific and Requires Postsynaptic Protein Kinase A and D1 Dopamine Receptor Signaling},
  author={Ed{\'e}n Flores-Barrera and Daniel R. Thomases and Li-jun Heng and Daryn K. Cass and Kuei Yuan Tseng},
  journal={Biological Psychiatry},
  year={2014},
  volume={75},
  pages={508-516}
}
BACKGROUND Refinement of mature cognitive functions, such as working memory and decision making, typically takes place during adolescence. The acquisition of these functions is linked to the protracted development of the prefrontal cortex (PFC) and dopamine facilitation of glutamatergic transmission. However, the mechanisms that support these changes during adolescence remain elusive. METHODS Electrophysiological recordings (in vitro and in vivo) combined with pharmacologic manipulations were… CONTINUE READING

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