Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.

@article{Fernandes2009LateBN,
  title={Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.},
  author={Daniel Fernandes and Regina Sordi and Let{\'i}cia Kramer Pacheco and Geisson Marcos Nardi and Bettina Tomio Heckert and Christina Gaspar Villela and Amanda Revoredo Lobo and Christina Barja-Fidalgo and Jamil Assreuy},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={328 3},
  pages={991-9}
}
Overproduction of nitric oxide and activation of soluble guanylate cyclase (sGC) are important in sepsis-induced hypotension and hyporesponsiveness to vasoconstrictors. A time course of the expression and activity of sGC in a sepsis model [cecal ligation and puncture (CLP)] was evaluated in rats. Soluble GC alpha-1 and beta-1 subunit mRNA levels increased in the lungs, but not in the aorta. However, in both tissues, the protein levels increased 24 h after sepsis and remained high for up to 48 h… CONTINUE READING
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