Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders

@article{Khatri2013LastingNA,
  title={Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders},
  author={Nidhi N. Khatri and Kimberly L. Simpson and Rick C. S. Lin and Ian A. Paul},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={1191-1200}
}
Perinatal exposure of rats to selective serotonin reuptake inhibitors (SSRIs) produces sensory and social abnormalities paralleling those seen in autistic spectrum disorders (ASDs). However, the possible mechanism(s) by which this exposure produces behavioral abnormalities is unclear. We hypothesized that the lasting effects of neonatal SSRI exposure are a consequence of abnormal stimulation of 5-HT1A and/or 5-HT1B receptors during brain development. We examined whether such stimulation would… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 66 references

Formation of dendrites and development of synaptic connections. Developmental neurobiology

  • M Jacobson
  • 1991
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…