Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects.

@article{Cagnotto1998LastingII,
  title={Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects.},
  author={Alfredo Cagnotto and Daniela Crespi and Laura Mancini and Claudia Manzoni and Mar{\'i}a Silvina Lo Presti and Manuela Gariboldi and Annamaria Vezzani and Tiziana Mennini},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 2},
  pages={850-7}
}
We examined the effect of kindling on serotonergic neurotransmission in the hippocampus by measuring serotonin (5-HT) release and uptake in hippocampal synaptosomes and 5-HT1A and 5-HT4 receptor subtypes during and at different times after electrical kindling of the dentate gyrus. Using quantitative receptor autoradiography, we found that binding of 8-[3H]hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) to 5-HT1A receptors was selectively increased by 20% on average (p < 0.05) in the… CONTINUE READING