Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.

@article{Seiffert2004LastingBB,
  title={Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.},
  author={Ernst J{\"u}rgen Seiffert and Jens P Dreier and Sebastian Ivens and Ingo Bechmann and Oren Tomkins and Uwe F Heinemann and Alon Friedman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 36},
  pages={
          7829-36
        }
}
Perturbations in the integrity of the blood-brain barrier have been reported in both humans and animals under numerous pathological conditions. Although the blood-brain barrier prevents the penetration of many blood constituents into the brain extracellular space, the effect of such perturbations on the brain function and their roles in the pathogenesis of cortical diseases are unknown. In this study we established a model for focal disruption of the blood-brain barrier in the rat cortex by… CONTINUE READING

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