Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry.

Abstract

Lasso peptides are natural products with a unique three dimensional structure resembling a lariat knot. They are from ribosomal origin and are post-translationally modified by two enzymes (B and C), one of which shares little similarity to enzymes outside of lasso peptide biosynthetic gene clusters and as such is a useful target for genome mining. In this… (More)
DOI: 10.1002/bip.22326

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