Lassa fever

@article{Houlihan2017LassaF,
  title={Lassa fever},
  author={Catherine F Houlihan and Ron H Behrens},
  journal={British Medical Journal},
  year={2017},
  volume={358}
}
Lassa fever is part of a group of conditions known as viral haemorrhagic fevers. Viral haemorrhagic fevers can be caused by viruses from several different families, all of which have the potential to cause disease with haemorrhagic features. Lassa fever—caused by infection with the Lassa virus—is named after the town in Nigeria where the first identified cases occurred. The natural reservoir of the Lassa virus is the multimammate rat (Mastomys natalensis), a rodent found commonly in rural areas… 

Understanding Lassa fever

TLDR
The results of a rapid genomic study of Lassa virus (LASV) from the cases of 2018 are presented, which have improved understanding of how the disease has been spreading in Nigeria and have led to informed and targeted disease-control strategies.

Investigation of a cross-border case of Lassa fever in West Africa

TLDR
This case report revealed how an epidemic-prone disease such as Lassa fever can rapidly spread across land borders and how such threat can be quickly controlled with communication and collaboration within the IHR framework.

Residual and Late Onset Symptoms Appeared in a Patient with Severe Fever with Thrombocytopenia in a Convalescence Stage

TLDR
A patient is reported presenting with hematospermia, fatigue, myalgia, alopecia, insomnia, and depression during the recovery phase of SFTS, suggesting common mechanisms between SFTS and other viral hemorrhagic fevers.

Factors associated with a confirmed Lassa fever outbreak in Eguare community of Esan West, Edo State, Nigeria: January-March, 2019

TLDR
Having contact with suspected case-patients and having dumpsites close to homes (p<0.01) were associated with Lassa fever infection among case-patient.

Potential for Seasonal Lassa Fever Case Exportation from Nigeria.

TLDR
Although a low probability of case exportation during this outbreak was quantified, countries with the greatest connectivity to Nigeria should be alert to the potential risks of Lassa fever importation and be prepared to manage infected individuals.

Boosting understanding of Lassa Fever virus epidemiology: Field testing a novel assay to identify past Lassa Fever virus infection in blood and oral fluids of survivors and unexposed controls in Sierra Leone

TLDR
Even at the performance levels achieved, the species-neutral DABA has the potential to facilitate the large-scale seroprevalence surveys needed to underpin essential developments in LF control, as well as support zoonotic investigations.

Identification of a clinical compound losmapimod that blocks Lassa virus entry

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TLDR
This document was created through collaboration with experts in infectious disease, community development, clinical management of viral haemorrhagic diseases, and qualitative research through a literature review using Ovid and PubMed, case analysis and surveys undertaken in the field, and relevant websites.

Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum.

TLDR
Data suggest that Lassa virus or specific LassA virus strains can persist in the central nervous system and thus contribute to neuropathogenesis and should be considered in West African patients or in travelers returning from this area who present only with fever and neurologic signs.

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TLDR
A low risk of transmission during the initial phase of symptomatic Lassa fever, even with high-risk exposures is indicated, although the risk may increase with progression of disease and increasing virus load.

Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever

TLDR
Development of rapid immunodiagnostics and research into the efficacy of current treatment options continues toward saving lives in west Africa as well as creating a line of defense against the nefarious use of LASV in bioterrorism settings.

Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice

TLDR
Compelling, indirect evidence revealed that parenteral drug rounds with sharing of syringes, conducted by minimally educated and supervised staff, fuelled the epidemic among patients, illustrating the high price exacted by the practice of modern medicine.

Acute sensorineural deafness in Lassa fever.

TLDR
Lassa fever is associated with an incidence of sensorineural hearing deficit which considerably exceeds that previously reported with any other postnatally acquired infection, and accounts for a prevalence of virus-related hearing impairment in the eastern province of Sierra Leone that is greater than that reported from anywhere else in the world.

Effect of environmental factors on aerosol‐induced lassa virus infection

TLDR
Organ tropism of aerosol‐induced Lassa virus infections in outbred guinea pigs was similar to that previously reported for inbred Guinea pigs infected by subcutaneous inoculation.

Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea.

TLDR
Three major risk factors in Gueckedou favoring Lassa virus transmission were observed: rodent infestation was much higher, food was more often stored uncovered and peridomestic rodents were hunted as a protein source by 91.5% of the population as opposed to 0% in Pita.

Diagnosis and Clinical Virology of Lassa Fever as Evaluated by Enzyme-Linked Immunosorbent Assay, Indirect Fluorescent-Antibody Test, and Virus Isolation

TLDR
The high sensitivity and specificity, capability for early diagnosis, and prognostic value of the ELISAs make them the diagnostic tests of choice for the detection of Lassa fever.

A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy.

TLDR
The risk of death from Lassa fever in the third trimester is significantlyHigher than that in the first two trimesters and higher than that for non-pregnant women, but evacuation of the uterus can significantly improve the mother's chance of survival.