Lassa Fever in West Africa: Evidence for an Expanded Region of Endemicity

  title={Lassa Fever in West Africa: Evidence for an Expanded Region of Endemicity},
  author={N. Sogoba and Heinz Feldmann and David Safronetz},
  journal={Zoonoses and Public Health},
Lassa virus (LASV) is endemic in Sierra Leone, Guinea and Liberia (known as the Mano River region) and Nigeria and Lassa fever cases from these countries are being reported annually. Recent investigations have found evidence for an expanded endemicity zone between the two known Lassa endemic regions indicating that LASV is more widely distributed throughout the Tropical Wooded Savanna ecozone in West Africa. 
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In the absence of effective treatment or vaccines to LASV, preventative measures against Lassa fever rely heavily on reducing or eliminating rodent exposure, increasing the knowledge base surrounding the virus and disease in communities, and diminishing the stigmas faced by LassA fever survivors.
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Though it’s endemic to parts of five West African countries, evidence suggests that Lassa virus is even more prevalent than previously thought.
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Erudition of rodent habitats, reproduction and fecundity, movement patterns, and spatial preferences are essential to institute preventative measures against Lassa fever.
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The genome sequence of LASV is isolated from the first case of acquired Lassa fever disease outside of Africa, and it is reported that this virus is a zoonotic, hemorrhagic fever-causing virus endemic in West Africa.
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The Lassa Virus (an Arenavirus) is found in West Africa, where it sometimes a severe hemorrhage illness called Lassa fever. The antivirus drug ribavirin is effective, but only if administered early
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Current knowledge is synthesized to show that extrapolations from past research have produced an incomplete picture of the incidence and distribution of LF, with negative consequences for policy planning, medical treatment and management interventions.
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Favipiravir was tested in Lassa virus–viremic macaques and it was found that 300 mg/kg daily for 2 weeks successfully treated infection.
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We report detection of Lassa virus and Crimean-Congo hemorrhagic fever virus infections in the area of Bamako, the capital of Mali. Our investigation found 2 cases of infection with each of these
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There is need for adequate training of health care workers regarding diagnostics, intensive care of patients under isolation, contact tracing, adequate precautionary measures in handling infectious laboratory specimens, control of the vector as well as care and disposal of infectious waste.
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The intention of this review is to summarize in particular the recent literature on LassA virus and Lassa fever.
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This document was created through collaboration with experts in infectious disease, community development, clinical management of viral haemorrhagic diseases, and qualitative research through a literature review using Ovid and PubMed, case analysis and surveys undertaken in the field, and relevant websites.
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