Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats.

@article{Wang2006LasofoxifeneEV,
  title={Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats.},
  author={Xiao-Ning Wang and Hollis A. Simmons and Christopher T. Salatto and Patricia G. Cosgrove and David D. Thompson},
  journal={Menopause},
  year={2006},
  volume={13 4},
  pages={609-20}
}
OBJECTIVE Lasofoxifene, a new selective estrogen-receptor modulator (SERM), shows efficacy in vaginal and vulvar atrophy in postmenopausal women. Here, we sought to explore the possible mechanisms of action for this effect in comparison with other SERMs using an immature ovariectomized rat model. DESIGN SERMs (lasofoxifene, raloxifene, and tamoxifen) and 17alpha-ethinyl estradiol were administered orally to immature ovariectomized rats daily for 1 or 4 days. Vaginal and uterine tissues were… CONTINUE READING

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