Laser-structured bacterial nanocellulose hydrogels support ingrowth and differentiation of chondrocytes and show potential as cartilage implants.

@article{Ahrem2014LaserstructuredBN,
  title={Laser-structured bacterial nanocellulose hydrogels support ingrowth and differentiation of chondrocytes and show potential as cartilage implants.},
  author={Hannes Ahrem and David Pretzel and Michaela Endres and Daniel Conrad and Julien Courseau and Hartmut M{\"u}ller and Raimund Jaeger and Christian Kaps and Dieter O Klemm and Raimund W. Kinne},
  journal={Acta biomaterialia},
  year={2014},
  volume={10 3},
  pages={1341-53}
}
The small size and heterogeneity of the pores in bacterial nanocellulose (BNC) hydrogels limit the ingrowth of cells and their use as tissue-engineered implant materials. The use of placeholders during BNC biosynthesis or post-processing steps such as (touch-free) laser perforation can overcome this limitation. Since three-dimensionally arranged channels may be required for homogeneous and functional seeding, three-dimensional (3-D) laser perforation of never-dried BNC hydrogels was performed… CONTINUE READING

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