Laser speckle contrast imaging of cerebral blood flow in freely moving animals.

@article{Miao2011LaserSC,
  title={Laser speckle contrast imaging of cerebral blood flow in freely moving animals.},
  author={Peng Miao and Hongyang Lu and Qi Liu and Yangyang Li and S. Tong},
  journal={Journal of biomedical optics},
  year={2011},
  volume={16 9},
  pages={090502}
}
We designed a miniature laser speckle imager that weighs ∼20 g and is 3.1-cm high for full-field high-resolution imaging of cerebral blood flow (CBF) in freely moving animals. Coherent laser light illuminates the cortex through a multimode optical fiber bundle fixed onto the supporting frame of the imager. The reflected lights are then collected by a miniature macrolens system and imaged by a high-resolution CMOS camera at a high frame rate (50 fps). Using this miniature imager, we achieve high… CONTINUE READING
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