Laser-induced nanobubbles safely ablate vitreous opacities in vivo

  title={Laser-induced nanobubbles safely ablate vitreous opacities in vivo},
  author={F{\'e}lix Sauvage and Van Phuc Nguyen and Yanxiu Li and Aranit Harizaj and J. Sebag and Dimitri Roels and Viktor Van Havere and Karen Peynshaert and Ranhua Xiong and Juan C. Fraire and Marie Jos{\'e} Tassignon and Katrien Remaut and Yannis M. Paulus and Kevin Braeckmans and Stefaan C. De Smedt},
  journal={Nature Nanotechnology},
In myopia, diabetes and ageing, fibrous vitreous liquefaction and degeneration is associated with the formation of opacities inside the vitreous body that cast shadows on the retina, appearing as ‘floaters’ to the patient. Vitreous opacities degrade contrast sensitivity function and can cause notable impairment in vision-related quality of life. Here we introduce ‘nanobubble ablation’ for safe destruction of vitreous opacities. Following intravitreal injection, hyaluronic acid-coated gold… 
3 Citations

ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery.

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Photodisruption of the Inner Limiting Membrane: Exploring ICG Loaded Nanoparticles as Photosensitizers

Application of ICG liposomes followed by laser treatment resulted in subtle disruption effects at the ILM where zones of fully ablated ILM were alternated by intact regions, improving the concept to a further extent.



Photo-Ablation of Human Vitreous Opacities by Light-Induced Vapor Nanobubbles.

Gold nanoparticle assisted photo-ablation may provide a safer, faster and more reliable destruction of vitreous opacities in the treatment of ophthalmologic diseases, and is attractive as it may be safer to the surrounding ocular tissues while at the same time being easier and faster to apply compared to YAG laser therapy.

Vitreous and Vision Degrading Myodesopsia

  • J. Sebag
  • Medicine
    Progress in Retinal and Eye Research
  • 2020

Cataracts induced by neodymium–yttrium-aluminium-garnet laser lysis of vitreous floaters

Two patients who underwent ND:YAG laser vitreolysis for symptomatic floaters, presented with decline in visual acuity in the treated eye after the laser procedure, indicating secondary cataract formation accompanied by loss of integrity of the posterior capsule is a potential complication of Nd: yttrium-aluminium-garnet laser vitREolysis.

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters.

It is demonstrated that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQD-2.

VITRECTOMY FOR FLOATERS: Prospective Efficacy Analyses and Retrospective Safety Profile

Floaters lower contrast sensitivity function, which normalizes after vitrectomy, seems effective and safe in alleviating the visual dysfunction induced by floaters.

Treatment of vitreous floaters with neodymium YAG laser.

The initial experience indicates that the use of neodymium YAG laser to treat vitreous floaters with serious psychological reactions is simple, safe, and effective.


Much evidence supports that ICG dye has a dose-dependent toxic effect on the retina, and the following recommendations to minimize toxic effects on the retinal tissue are proposed.