Inductively coupled plasma mass spectrometry (ICP MS): a versatile tool.
- Adrian A Ammann
- Journal of mass spectrometry : JMS
Metals are not homogeneously distributed in organ tissues. Although most mapping techniques, such as histologic staining methods, have been developed for element imaging on a subcellular level, many suffer from either low precision or poor detection limits. Therefore, small variations in elemental distribution cannot be identified. We have developed a method for two-dimensional mapping of trace elements to identify the influence of metabolic zonation by the liver on trace element distribution.