• Corpus ID: 179386477

Las orexinas dos péptidos hipotalámicos: Su localización y acción en el eje hipotálamo-hipófisis-gónadas

  title={Las orexinas dos p{\'e}ptidos hipotal{\'a}micos: Su localizaci{\'o}n y acci{\'o}n en el eje hipot{\'a}lamo-hip{\'o}fisis-g{\'o}nadas},
  author={Norma G{\'o}mez-Torres and Ulises Aguilera-Reyes and Oscar Galicia-Castillo},
Orexins A and B are two neuropeptides synthesized in the lateral hypothalamus, perifornical area and dorsomedial hypothalamus. Bothare derived from the proteolytic cleavage of a protein called pre-pro-orexin; they together exert their biological effects through two G protein-coupled receptors named OX1R and OX2R. The axons of theorexinergic neurons are distributed almost throughout the central nervous system and they can be found in some organs including the reproductive tract of both sexes… 

Omental transplantation for neuroendocrinological disorders.

  • H. Rafael
  • Medicine
    American journal of neurodegenerative disease
  • 2015
Surgical method has best advantages than the bariatric surgery, against obesity and type 2 diabetes mellitus and essential arterial hypertension, due to revascularization of the hypothalamic nuclei.

Review Article Omental transplantation for neuroendocrinological disorders

Neurosurgical evidences show that the aging process is initiated between 25 to 30 years of age, in the ar- cuate nucleus of the hypothalamus. Likewise, experimental and neurosurgical findings



Orexin A and its role in the regulation of the hypothalamo-pituitary axes in the rat.

Orexin A is involved in food intake and energy expenditure in many species, but also plays an important role in the regulation of the hypothalamo-pituitary axes, and its receptors are widely distributed in the central nervous system (CNS) and peripheral organs suggesting the pleiotropic functions of this peptide.

Expression of Orexin A and its Receptor 1 in the Bovine Urethroprostatic Complex

These findings provide the first evidence for the presence of oxA and ox1R in the urethroprostatic complex of the cattle and demonstrate that both proteins are locally synthesized, thus suggesting a role for oxA on both physiological and pathological functioning of the complex.

Evidence that Orexin‐Containing Neurones Provide Direct Input to Gonadotropin‐Releasing Hormone Neurones in the Ovine Hypothalamus

An integral role for ORX in the regulation of GnRH cells in the sheep is suggested and evidence of a novel mechanism whereby leptin can influence reproductive neuroendocrine function is provided.

Differential expression of orexin receptors 1 and 2 in the rat brain

The differential distribution of oxin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX2R receptor in regulating sleep state stability.

Expression of orexin A and its receptor 1 in the human prostate

The results definitely demonstrate the expression of OXA and OX1R in the human prostate, and suggest an active role for them in the metabolism of the gland.

The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding

These peptides appear to be part of a complex circuit that integrates aspects of energy metabolism, cardiovascular function, hormone homeostasis, and sleep‐wake behaviors.

Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.

An increased ovarian expression of both OX (1) and OX(2), only during proestrous afternoon, is demonstrated, and its hormone dependence but not dependence on the dark-light cycle is demonstrated.

Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.

The expression of OR receptors and their signaling characteristics in the human male reproductive system are investigated and it is demonstrated that both OX1R and OX2R are expressed in the testis, epididymis, penis, and seminal vesicle, whereas prepro-OR was expressed only in the epididsymis and penis.