• Corpus ID: 179386477

Las orexinas dos péptidos hipotalámicos: Su localización y acción en el eje hipotálamo-hipófisis-gónadas

@inproceedings{GmezTorres2014LasOD,
  title={Las orexinas dos p{\'e}ptidos hipotal{\'a}micos: Su localizaci{\'o}n y acci{\'o}n en el eje hipot{\'a}lamo-hip{\'o}fisis-g{\'o}nadas},
  author={Norma G{\'o}mez-Torres and Ulises Aguilera-Reyes and Oscar Galicia-Castillo},
  year={2014}
}
Orexins A and B are two neuropeptides synthesized in the lateral hypothalamus, perifornical area and dorsomedial hypothalamus. Bothare derived from the proteolytic cleavage of a protein called pre-pro-orexin; they together exert their biological effects through two G protein-coupled receptors named OX1R and OX2R. The axons of theorexinergic neurons are distributed almost throughout the central nervous system and they can be found in some organs including the reproductive tract of both sexes… 

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TLDR
Orexin A is involved in food intake and energy expenditure in many species, but also plays an important role in the regulation of the hypothalamo-pituitary axes, and its receptors are widely distributed in the central nervous system (CNS) and peripheral organs suggesting the pleiotropic functions of this peptide.

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TLDR
These findings provide the first evidence for the presence of oxA and ox1R in the urethroprostatic complex of the cattle and demonstrate that both proteins are locally synthesized, thus suggesting a role for oxA on both physiological and pathological functioning of the complex.

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TLDR
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TLDR
The differential distribution of oxin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX2R receptor in regulating sleep state stability.

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TLDR
The results definitely demonstrate the expression of OXA and OX1R in the human prostate, and suggest an active role for them in the metabolism of the gland.

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TLDR
These peptides appear to be part of a complex circuit that integrates aspects of energy metabolism, cardiovascular function, hormone homeostasis, and sleep‐wake behaviors.

Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.

TLDR
An increased ovarian expression of both OX (1) and OX(2), only during proestrous afternoon, is demonstrated, and its hormone dependence but not dependence on the dark-light cycle is demonstrated.

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TLDR
The expression of OR receptors and their signaling characteristics in the human male reproductive system are investigated and it is demonstrated that both OX1R and OX2R are expressed in the testis, epididymis, penis, and seminal vesicle, whereas prepro-OR was expressed only in the epididsymis and penis.