Corpus ID: 179386477

Las orexinas dos péptidos hipotalámicos: Su localización y acción en el eje hipotálamo-hipófisis-gónadas

  title={Las orexinas dos p{\'e}ptidos hipotal{\'a}micos: Su localizaci{\'o}n y acci{\'o}n en el eje hipot{\'a}lamo-hip{\'o}fisis-g{\'o}nadas},
  author={Norma G{\'o}mez-Torres and Ulises Aguilera-Reyes and Oscar Galicia-Castillo},
Orexins A and B are two neuropeptides synthesized in the lateral hypothalamus, perifornical area and dorsomedial hypothalamus. Bothare derived from the proteolytic cleavage of a protein called pre-pro-orexin; they together exert their biological effects through two G protein-coupled receptors named OX1R and OX2R. The axons of theorexinergic neurons are distributed almost throughout the central nervous system and they can be found in some organs including the reproductive tract of both sexes… Expand
2 Citations
Review Article Omental transplantation for neuroendocrinological disorders
Neurosurgical evidences show that the aging process is initiated between 25 to 30 years of age, in the ar- cuate nucleus of the hypothalamus. Likewise, experimental and neurosurgical findingsExpand
Omental transplantation for neuroendocrinological disorders.
  • H. Rafael
  • Medicine
  • American journal of neurodegenerative disease
  • 2015
Surgical method has best advantages than the bariatric surgery, against obesity and type 2 diabetes mellitus and essential arterial hypertension, due to revascularization of the hypothalamic nuclei. Expand


Fisiología de la reproducción: hormona liberadora de gonadotrofinas
Advances in the knowledge of this area have shown a clinical usefullness, illustrated by GnRH analogs which are used in the treatment of early puberty, ovarian cysts and endometriosis. Expand
Distribution of orexin B and its relationship with GnRH in the pig hypothalamus.
Orexin B may regulate reproduction by altering LH release in the hypothalamus using double immunofluorescence and laser-scanning confocal microscopy, and immunoreactive fibres were distributed throughout the central nervous system. Expand
Orexin A and its role in the regulation of the hypothalamo-pituitary axes in the rat.
Orexin A is involved in food intake and energy expenditure in many species, but also plays an important role in the regulation of the hypothalamo-pituitary axes, and its receptors are widely distributed in the central nervous system (CNS) and peripheral organs suggesting the pleiotropic functions of this peptide. Expand
Expression of Orexin A and its Receptor 1 in the Bovine Urethroprostatic Complex
These findings provide the first evidence for the presence of oxA and ox1R in the urethroprostatic complex of the cattle and demonstrate that both proteins are locally synthesized, thus suggesting a role for oxA on both physiological and pathological functioning of the complex. Expand
Evidence that Orexin‐Containing Neurones Provide Direct Input to Gonadotropin‐Releasing Hormone Neurones in the Ovine Hypothalamus
An integral role for ORX in the regulation of GnRH cells in the sheep is suggested and evidence of a novel mechanism whereby leptin can influence reproductive neuroendocrine function is provided. Expand
Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers.
The present study found that, although Y4-positive orexin fibers are in present in the area of Gn RH neurons, they never come in close contact with GnRH neurons, suggesting that Y4 receptor modulation of LH release is likely to be indirect through orexIn cell bodies and that orex in modulates GnRH neuron directly via OX-R1. Expand
Differential expression of orexin receptors 1 and 2 in the rat brain
The differential distribution of oxin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX2R receptor in regulating sleep state stability. Expand
Expression of orexin A and its receptor 1 in the human prostate
The results definitely demonstrate the expression of OXA and OX1R in the human prostate, and suggest an active role for them in the metabolism of the gland. Expand
The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
These peptides appear to be part of a complex circuit that integrates aspects of energy metabolism, cardiovascular function, hormone homeostasis, and sleep‐wake behaviors. Expand
Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.
An increased ovarian expression of both OX (1) and OX(2), only during proestrous afternoon, is demonstrated, and its hormone dependence but not dependence on the dark-light cycle is demonstrated. Expand