Laryngeal cancer and occupational exposure to sulfuric acid.

  title={Laryngeal cancer and occupational exposure to sulfuric acid.},
  author={Colin L. Soskolne and Elaine A. Zeighami and Noor Hanis and Lawrence L. Kupper and N Herrmann and Jon Amsel and Judith S. Mausner and Jeanne Mager Stellman},
  journal={American journal of epidemiology},
  volume={120 3},
Workers on an ethanol unit which used sulfuric acid in strong concentrations at a large refinery and chemical plant in Baton Rouge, Louisiana were reported, in 1979, at excess risk for upper respiratory cancer. The carcinogen implicated by indirect evidence was diethyl sulfate. However, with the continued use of sulfuric acid in the same plant, and with additional cases not attributable to the ethanol process, the hypothesis of an association between sulfuric acid exposure and upper respiratory… 

Tables from this paper

Strong inorganic acid mists containing sulfuric acid.

  • Medicine
    Report on carcinogens : carcinogen profiles
  • 2002
A Canadian population-based case-control study found a doserelated risk of laryngeal cancer for workers exposed to sulfuric acid mist, after controlling for tobacco and alcohol use and using only the most specific exposure scale.

Occupational exposure to sulfuric acid in southern Ontario, Canada, in association with laryngeal cancer.

A case-referent study, designed to test associations between asbestos, nickel, and the development of laryngeal cancer, was conducted in southern Ontario in 1977-1979 and revealed statistically significant odds ratios when tobacco and alcohol were controlled.

Lung cancer near an industrial site in Lithuania with major emissions of airway irritants

It is probable that higher smoking rates constitute the main reason for the increased lung cancer risk among men in this area, and smoking levels appeared more pronounced among study controls than in the rest of the country.

Upper aerodigestive cancer in battery manufacturers and steel workers exposed to mineral acid mists.

Findings in a cohort study and nested case-control study of upper aerodigestive tumours in men employed since 1950 at two battery plants and two steel works in Britain indicate that any risk from exposures to sulphuric and hydrochloric acid below 1 mg/m3 is small.

Upper aerodigestive cancer in battery manufacturers and steel workers exposed to mineral acid mists.

Overall mortality among the men definitely to acid mists, overall mortality was less than the national (standardised mortality ratio 95% as was from all cancers specifically from cancer the larynx total of incident or fatal cases of upper aerodigestive cancer during follow up).

Incidence of laryngeal cancer and exposure to acid mists.

Excess smoking by the exposed cohort compared with the United States population resulted in an upward adjustment of the expected number of cases of laryngeal cancer to 3.92, consistent with four other studies published since 1981.

Laryngeal cancer incidence among workers exposed to acid mists (United States)

The findings are consistent with previous findings from this cohort and from most other studies, and tend to confirm IARC's classification of acid mists as a human carcinogen.


Lung cancer mortality in workers exposed to sulfuric acid mist and other acid mists. Lung cancer and hydrogen chloride exposure: results from a nested case-control study of chemical workers. An

Laryngeal and hypopharyngeal cancers and occupational exposure to formaldehyde and various dusts: a case-control study in France

Exposure to formaldehyde and coal dust may increase the risk of hypopharyngeal cancer, according to a case-control study conducted in France.

A Population-Based Case-Control Study of Occupational Exposure to Acids and the Risk of Lung Cancer: Evidence for Specificity of Association

No excess risk for overall lung cancer was associated with any of the acids, and effect modification by gender could not be identified, reinforcing more recent toxicological data that suggest specificity to the larynx.



An association of upper respiratory cancer with exposure to diethyl sulfate.

A morbidity and mortality study of workers at an alcohol manufacturing plant which included several weak acid isopropyl alcohol units and a strong acid ethanol unit is described, leading to the tentative conclusion that diethyl sulfate was primarily responsible for the ethanol unit cancer cases.

Work-related risk factors for laryngeal cancer.

A case-control study to identify employment-related risk factors for laryngeal cancer conducted in Richmond County, Georgia, found rate ratio estimates above 3.0 for farmers, textile processors who separated, filtered or dried textile fibers, and for all laborers and maintenance personnel.

[A case of industrial origin of laryngeal carcinoma (author's transl)].

A patient working with insulating materials on industrial heating systems, impressevely demonstrates the transformation of chronic laryngitis into a carcinoma in the course of years, brought about by industrial influences and thus proving the exogenous origin of this genesis.

Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses.

The extremely low proportion of cancers of the nose and nasal cavities together with the very high proportion of cancer of the maxillary sinus in Japan are in contrast with a much higher relative frequency of Nose and nasal cavity cancer in other countries.

Toxicity of sulfuric acid mist.

Various species were exposed to sulfuric acid mist and lesions included the following: degeneration of respiratory tract epithelium, hyperemia, edema, focal hemorrhage, patchy atelectasis, and emphysema.

Management of the Patient with Cancer

Management of the Patient With Cancer is 1067 pages of contributions in 40 chapters devoted to a comprehensive goal of complete coverage of a vast field as of 1965.

Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.

Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.

Epidemiology of laryngeal cancer.