Larval crowding accelerates C. elegans development and reduces lifespan

@inproceedings{Ludewig2017LarvalCA,
  title={Larval crowding accelerates C. elegans development and reduces lifespan},
  author={Andreas Hanno Ludewig and Clotilde Gimond and Joshua C. Judkins and Staci Thornton and Dania C. Pulido and Robert J. Micikas and Frank D{\"o}ring and Adam Antebi and Christian Braendle and Frank C Schroeder},
  booktitle={PLoS genetics},
  year={2017}
}
Environmental conditions experienced during animal development are thought to have sustained impact on maturation and adult lifespan. Here we show that in the model organism C. elegans developmental rate and adult lifespan depend on larval population density, and that this effect is mediated by excreted small molecules. By using the time point of first egg laying as a marker for full maturity, we found that wildtype hermaphrodites raised under high density conditions developed significantly… CONTINUE READING
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