Larval antigen molecules recognized by adult immune cells of inbred Xenopus laevis: partial characterization and implication in metamorphosis.

@article{Izutsu2002LarvalAM,
  title={Larval antigen molecules recognized by adult immune cells of inbred Xenopus laevis: partial characterization and implication in metamorphosis.},
  author={Yumi Izutsu and Shin Tochinai and Mitsugu Ma{\'e}no and Yoshinobu Yanagawa and Kazunori On{\'o}e},
  journal={Development, growth & differentiation},
  year={2002},
  volume={44 6},
  pages={
          477-88
        }
}
It has been shown that larval skin (LS) grafts are rejected by an inbred strain of adult Xenopus, which suggests a mechanism of metamorphosis by which larval cells are recognized and attacked by the newly differentiating immune system, including T lymphocytes. In an attempt to define the larval antigenic molecules that are targeted by the adult immune system, anti-LS antibodies (IgY) were produced by immunizing adult frogs with syngeneic LS grafts. The antigen molecules that reacted… CONTINUE READING
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