Larval RNAi in Drosophila?

  title={Larval RNAi in Drosophila?},
  author={Sherry Miller and Susan J. Brown and Yoshinori Tomoyasu},
  journal={Development Genes and Evolution},
RNA interference (RNAi) has become a common method of gene knockdown in many model systems. To trigger an RNAi response, double-stranded RNA (dsRNA) must enter the cell. In some organisms such as Caenorhabditis elegans, cells can take up dsRNA from the extracellular environment via a cellular uptake mechanism termed systemic RNAi. However, in the fruit fly Drosophila melanogaster, it is widely believed that cells are unable to take up dsRNA, although there is little published data to support… CONTINUE READING


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