Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor

  title={Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor},
  author={Yi-Xiang Qi and Ren-ying Xia and Ya-su Wu and David Stanley and Jia Huang and Gōngy{\'i}n Y{\`e}},
  journal={Journal of Neurochemistry},
  pages={767 - 777}
The biogenic amine serotonin (5‐hydroxytryptamine, 5‐HT) is a neurotransmitter in vertebrates and invertebrates. It acts in regulation and modulation of many physiological and behavioral processes through G‐protein‐coupled receptors. Five 5‐HT receptor subtypes have been reported in Drosophila that share high similarity with mammalian 5‐HT1A, 5‐HT1B, 5‐HT2A, 5‐HT2B, and 5‐HT7 receptors. We isolated a cDNA (Pr5‐HT8) from larval Pieris rapae, which shares relatively low similarity to the known 5… 

Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka)

Experiments demonstrated that treatment with 5-HT triggered a significant increase in intracellular cAMP level in a dose-dependent manner and induced a rapid internalisation of Aj5-HT4R fused with enhanced green fluorescent protein from the cell surface into the cytoplasm.

Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor

This study reports the first 5HT receptor from S. exigua and provides its specific inhibitor designed from bacterial metabolites and their derivatives, screened with respect to cellular immune responses associated with Se-5HTR.

Molecular Cloning and Expression Analysis of 5-hydroxytryptamine Receptor 7 in Ant Polyrhachis vicina Roger (Hymenoptera: Formicidae)

The results suggest that the Pv5-HT7 receptor may have specific functions in regulating the development of P. vicina, especially in adult formation and caste differentiation, feeding and caring behaviors of workers in the nest, and in theDevelopment of motor organs and mating behaviors in males.

Invertebrate serotonin receptors: a molecular perspective on classification and pharmacology

  • A. Tierney
  • Biology
    Journal of Experimental Biology
  • 2018
An overview of heterologously expressed receptors is provided, which considers evolutionary relationships among them, classification based on these relationships and nomenclature that reflects classification, and transduction pathways and pharmacological profiles are compared.

Identification, functional characterization, and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus

A separate serotonin receptor type may mediate cardiomodulatory effects controlled by serotonin in R. prolixus, which shares sequence similarity to the vertebrate serotonin type 2 receptors, and a distinct agonist/antagonist profile is indicated.

An insect serotonin receptor mediates cellular immune responses and its inhibition by phenylethylamide derivatives from bacterial secondary metabolites

The first 5HT receptor from S. exigua is reported and its specific inhibitor designed from bacterial metabolites and their derivatives, which showed high immunosuppressive activities along with specific and competitive inhibition activity for Se-5HTR.

Biogenic amine biosynthetic and transduction genes in the endoparasitoid wasp Pteromalus puparum (Hymenoptera: Pteromalidae).

It is inferred that BA signaling is a fundamental component of the organismal organization, homeostasis and operation in parasitoids, some of the smallest insects.



Am5‐HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera)

This study marks the first comprehensive characterization of a serotonin receptor in the honeybee and should facilitate further analysis of the role(s) of the receptor in mediating the various central and peripheral effects of 5‐HT.

Characterization of the 5-HT1A receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior

The data presented here mark the first comprehensive study—from gene to behavior—of a 5-HT1A receptor in the honeybee, paving the way for the eventual elucidation of additional roles of this receptor subtype in the physiology and behavior of this social insect.

Pharmacological Characterization of a 5-HT1-Type Serotonin Receptor in the Red Flour Beetle, Tribolium castaneum

The pharmacological profile of the 5-HT1 receptor was studied and it was demonstrated that α-methylserotonin, 5-methoxytryptamine and 5-carboxamidotryptamine acted as agonists and Prazosin, methiothepin and methysergide were the most potent antagonists and showed competitive inhibition in presence of 5- HT.

Function and Distribution of 5-HT2 Receptors in the Honeybee (Apis mellifera)

This study marks the first molecular and pharmacological characterization of two 5-HT2 receptor subtypes in the same insect species and should facilitate further attempts to unravel central and peripheral effects of serotonin mediated by these receptors.

In vitro expression and pharmacology of the 5‐HT7‐like receptor present in the mosquito Aedes aegypti tracheolar cells and hindgut‐associated nerves

The cloning of a 5‐hydroxytryptamine receptor (Aedes 5‐HT7‐like receptor) from adult Aedes aegypti and the first report on the functional expression of a mosquito neurohormone receptor are reported.

Molecular and Pharmacological Characterization of Serotonin 5-HT2α and 5-HT7 Receptors in the Salivary Glands of the Blowfly Calliphora vicina

This study represents the first comprehensive molecular and pharmacological characterization of two 5-HT receptors in the blowfly and permits the analysis of the physiological role of these receptors, even when co-expressed in cells, and of the modes of interaction between the Ca2+- and cAMP-signalling cascades.

Characterization of a β-adrenergic-like octopamine receptor from the rice stem borer (Chilo suppressalis)

A rather unique pharmacological profile for CsOA2B2 is observed through measurements of cAMP, the invertebrate counterpart of adrenaline and noradrenaline, which is important for a better functional understanding of this receptor as well as for practical applications in the development of environmentally sustainable pesticides.

Identification and expression analysis of the genes involved in serotonin biosynthesis and transduction in the field cricket Gryllus bimaculatus

The identification of 5‐HT‐related genes in the field cricket Gryllus bimaculatus DeGeer and expression analysis of the tryptophan hydroxylase gene TRH and phenylalanine‐tryptophan Hydroxylases gene TPH suggested that two 5‐ HT synthesis pathways co‐exist in the cricket neuronal tissues.

Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation.

The isolation of a cDNA coding for a Drosophila melanogaster serotonin receptor that displays a sequence, a gene organization, and pharmacological properties typical of the mammalian 5-HT2 serotonin receptor subtype is reported.