Larger dispersion of INa in female dog ventricle as a mechanism for gender-specific incidence of cardiac arrhythmias.

Abstract

AIMS Women have a higher incidence of long QT-related arrhythmias, whereas men exhibit a higher incidence of Brugada syndrome (BrS). The cardiac sodium current (I(Na)) is associated with arrhythmias in BrS and long QT-syndrome (LQTS) and conduction disease. Although a great deal of work has been performed to explain how heterogeneous distribution of… (More)
DOI: 10.1093/cvr/cvn255

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