Larger Number of Invariant Natural Killer T-Cells in Allogeneic Peripheral Blood Stem Cell Grafts Is Associated with Improved Graft-Versus-Host Disease-Free, Progression-Free Survival after Allogeneic Stem Cell Transplantation

@inproceedings{Malard2015LargerNO,
  title={Larger Number of Invariant Natural Killer T-Cells in Allogeneic Peripheral Blood Stem Cell Grafts Is Associated with Improved Graft-Versus-Host Disease-Free, Progression-Free Survival after Allogeneic Stem Cell Transplantation},
  author={Florent Malard and Myriam Labopin and Patrice Chevallier and Thierry Guillaume and Alix Duquesne and Sophie Derenne and Eolia Brissot and Marc Gr{\'e}goire and Philippe Moreau and Philippe Saas and Mohamad Mohty and Bb{\'e}atrice Gaugler},
  year={2015}
}
Introduction The therapeutic efficacy of allogeneic stem cell transplantation (allo-SCT) relies mostly on the immune-mediated graft- versus -tumor (GVT) activity of the graft. However the beneficial effect of GVT is counterbalanced by the destruction of the tissues of the recipient by the immune effectors of the donor, termed graft- versus -host disease (GVHD). Despite G-CSF mobilized peripheral blood stem cells (PBSC) being used for more than 20 years, literature investigating the impact of… CONTINUE READING

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