Large-scale study of the interactions between proteins involved in type IV pilus biology in Neisseria meningitidis: characterization of a subcomplex involved in pilus assembly.

@article{Georgiadou2012LargescaleSO,
  title={Large-scale study of the interactions between proteins involved in type IV pilus biology in Neisseria meningitidis: characterization of a subcomplex involved in pilus assembly.},
  author={Michaella Georgiadou and Marta Castagnini and Gouzel Karimova and Daniel Ladant and Vladimir Pelicic},
  journal={Molecular microbiology},
  year={2012},
  volume={84 5},
  pages={857-73}
}
The functionally versatile type IV pili (Tfp) are one of the most widespread virulence factors in bacteria. However, despite generating much research interest for decades, the molecular mechanisms underpinning the various aspects of Tfp biology remain poorly understood, mainly because of the complexity of the system. In the human pathogen Neisseria meningitidis for example, 23 proteins are dedicated to Tfp biology, 15 of which are essential for pilus biogenesis. One of the important gaps in our… CONTINUE READING