Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release

@article{Hansen2004LargescaleSO,
  title={Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release},
  author={Sara Kristine Hansen and Anette Prior Gjesing and S\oren Kofoed Rasmussen and Charlotte Gl{\"u}mer and S\oren A. Urhammer and Gitte Andersen and Chrisian S Rose and Thomas Drivsholm and Signe K Torekov and Dorit Packert Jensen and Claus Thorn Ekstr\om and Knut Borch-Johnsen and Torben J\orgensen and Mark I. McCarthy and Torben Hansen and Oluf Pedersen},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1079-1087}
}
The class III allele of the variable-number-of-tandem-repeats polymorphism located 5′ of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistently, that the class III allele plays a role in glucose-induced insulin response among NGT individuals. We investigated the impact of the class III allele on Type 2 diabetes susceptibility in a case-control study involving 1462 Type 2 diabetic patients and 4931 NGT… CONTINUE READING