Large-scale structural changes in the sarcoplasmic reticulum ATPase appear essential for calcium transport.

@article{Blasie1990LargescaleSC,
  title={Large-scale structural changes in the sarcoplasmic reticulum ATPase appear essential for calcium transport.},
  author={J. Kent Blasie and D Pascolini and F J Asturias and Leo G. Herbette and D H Pierce and Antonio Giorgio Scarpa},
  journal={Biophysical journal},
  year={1990},
  volume={58 3},
  pages={687-93}
}
Model refinement calculations utilizing the results from time-resolved x-ray diffraction studies indicate that specific, large-scale changes (i.e., structural changes over a large length scale or long range) occur throughout the cylindrically averaged profile structure of the sarcoplasmic reticulum ATPase upon its phosphorylation during calcium active transport. Several physical-chemical factors, all of which slow the kinetics of phosphoenzyme formation, induce specific, large-scale changes… CONTINUE READING

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