Large scale sequencing by hybridization

  title={Large scale sequencing by hybridization},
  author={Ron Shamir and Dekel Tsur},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={9 2},
Sequencing by hybridization is a method for reconstructing a DNA sequence based on its k-mer content. This content, called the spectrum of the sequence, can be obtained from hybridization with a universal DNA chip. However, even with a sequencing chip containing all 49 9-mers and assuming no hybridization errors, only about 400 bases-long sequences can be reconstructed unambiguously. Drmanac et al. suggested sequencing long DNA targets by obtaining spectra of many short overlapping fragments of… CONTINUE READING
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