Large-scale screening for novel low-affinity extracellular protein interactions.

  title={Large-scale screening for novel low-affinity extracellular protein interactions.},
  author={K Mark W Bushell and Christian Soellner and Benjamin Schuster-Boeckler and Alex Bateman and Gavin J. Wright},
  journal={Genome research},
  volume={18 4},
Extracellular protein-protein interactions are essential for both intercellular communication and cohesion within multicellular organisms. Approximately a fifth of human genes encode membrane-tethered or secreted proteins, but they are largely absent from recent large-scale protein interaction datasets, making current interaction networks biased and incomplete. This discrepancy is due to the unsuitability of popular high-throughput methods to detect extracellular interactions because of the… CONTINUE READING
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