Large-scale reconstruction and phylogenetic analysis of metabolic environments.


The topology of metabolic networks may provide important insights not only into the metabolic capacity of species, but also into the habitats in which they evolved. Here we introduce the concept of a metabolic network's "seed set"--the set of compounds that, based on the network topology, are exogenously acquired--and provide a methodological framework to… (More)
DOI: 10.1073/pnas.0806162105


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@article{Borenstein2008LargescaleRA, title={Large-scale reconstruction and phylogenetic analysis of metabolic environments.}, author={Elhanan Borenstein and Martin Kupiec and Marcus W. Feldman and Eytan Ruppin}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2008}, volume={105 38}, pages={14482-7} }