Large-scale proteomics analysis of the human kinome.

  title={Large-scale proteomics analysis of the human kinome.},
  author={Felix S Oppermann and Florian Gnad and Jesper V. Olsen and Renate Hornberger and Zolt{\'a}n Greff and Gy{\"o}rgy K{\'e}ri and Matthias Mann and Henrik Daub},
  journal={Molecular & cellular proteomics : MCP},
  volume={8 7},
Members of the human protein kinase superfamily are the major regulatory enzymes involved in the activity control of eukaryotic signal transduction pathways. As protein kinases reside at the nodes of phosphorylation-based signal transmission, comprehensive analysis of their cellular expression and site-specific phosphorylation can provide important insights into the architecture and functionality of signaling networks. However, in global proteome studies, low cellular abundance of protein… CONTINUE READING
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