Large-scale proteomic characterization of melanoma expressed proteins reveals nestin and vimentin as biomarkers that can potentially distinguish melanoma subtypes.

@article{Qendro2014LargescalePC,
  title={Large-scale proteomic characterization of melanoma expressed proteins reveals nestin and vimentin as biomarkers that can potentially distinguish melanoma subtypes.},
  author={Veneta Qendro and Deborah H. Lundgren and Karim Rezaul and Forrest Mahony and Nicholas Ferrell and Andrew S. Bi and Ardian Latifi and Daniyal Chowdhury and Steven Gygi and Wilhelm Haas and Lori Wilson and Michael Troy Murphy and David K. M. Han},
  journal={Journal of proteome research},
  year={2014},
  volume={13 11},
  pages={
          5031-40
        }
}
Melanoma is an aggressive type of skin cancer, which accounts for only 4% of skin cancer cases but causes around 75% of skin cancer deaths. Currently, there is a limited set of protein biomarkers that can distinguish melanoma subtypes and provide an accurate prognosis of melanoma. Thus, we have selected and profiled the proteomes of five different melanoma cell lines from different stages of progression in comparison with a normal melanocytes using tandem mass spectrometry. We also profiled the… CONTINUE READING
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