Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis.

Abstract

The two-step functionalization of 30,000 SynPhase Polystyrene (PS) Lanterns in a 30-L glass process reactor is described. The first step involves bromination of the polystyrene backbone to afford an aryl bromide handle. Subsequent Suzuki cross coupling with the trialkylborane generated in situ from the reaction of allyldiisopropyl(4-methoxyphenyl)silane and… (More)
DOI: 10.1021/cc8000986

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Cite this paper

@article{Ryba2009LargeSP, title={Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis.}, author={Troy D Ryba and Kristopher M Depew and Lisa A. Marcaurelle}, journal={Journal of combinatorial chemistry}, year={2009}, volume={11 1}, pages={110-6} }