Large-scale prediction of phenotype: concept.

@article{Varner2000LargescalePO,
  title={Large-scale prediction of phenotype: concept.},
  author={Jeffrey D. Varner},
  journal={Biotechnology and bioengineering},
  year={2000},
  volume={69 6},
  pages={664-78}
}
The capability to gather organism wide data has far outstripped the ability to understand it. Transforming large-scale data into a "better" cell requires tools that integrate physiology with its environment. One such tool is large-scale mathematical models that marry stoichiometry and kinetics with metabolic regulation and control. It is straightforward to determine stoichiometry (at least for central pathways), and kinetics can be roughly approximated where need be. However, the molecular… CONTINUE READING

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