Large-scale pathways-based association study in amyotrophic lateral sclerosis.

  title={Large-scale pathways-based association study in amyotrophic lateral sclerosis.},
  author={Dalia Kasperavi{\vc}iūtė and Mike E Weale and Kevin V. Shianna and Gareth T. Banks and Claire L Simpson and Valerie K. Hansen and Martin R. Turner and Christopher E. Shaw and Ammar Al-Chalabi and Hardev Singh Pall and Emily F. Goodall and Karen E. Morrison and Richard W. Orrell and Marcus Beck and Sibylle Jablonka and Michael Sendtner and Alice Brockington and Paul G. Ince and Judith Hartley and Hannah Nixon and Pamela J Shaw and Giampietro Schiavo and Nicholas Wood and David K. Goldstein and Elizabeth M. C. Fisher},
  journal={Brain : a journal of neurology},
  volume={130 Pt 9},
Sporadic amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, most likely results from complex genetic and environmental interactions. Although a number of association studies have been performed in an effort to find genetic components of sporadic ALS, most of them resulted in inconsistent findings due to a small number of genes investigated in relatively small sample sizes, while the replication of results was rarely attempted. Defects in retrograde axonal transport… CONTINUE READING