Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis.

  title={Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis.},
  author={Maria Assunta Rocca and Paola Valsasina and Vittorio Martinelli and Paolo Misci and Andrea Falini and Giancarlo Comi and Massimo Filippi},
  volume={79 14},
OBJECTIVES Given that multiple sclerosis (MS) hits diffusely the brain hemispheres, we hypothesized that this should result in a distributed pattern of functional connectivity (FC) abnormalities. To this aim, we assessed, using resting-state (RS) fMRI, intrinsic FC and functional network connectivity (FNC) of brain large-scale neuronal networks from 85 patients with relapsing-remitting MS (RRMS) and 40 matched controls. METHODS Independent component analysis was used to analyze RS fMRI data… CONTINUE READING
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