Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function.

@article{Goldowitz2004LargescaleMO,
  title={Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function.},
  author={Dan Goldowitz and Wayne N. Frankel and Joseph S Takahashi and Martha Holtz-Vitaterna and Carol Bult and Warren A. Kibbe and Jay Snoddy and Yanxia Li and Stephanie Pretel and Jeana Yates and Douglas James Swanson},
  journal={Brain research. Molecular brain research},
  year={2004},
  volume={132 2},
  pages={105-15}
}
N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Pattern Recognition of Sleep in Rodents Using Piezoelectric Signals Generated by Gross Body Movements

IEEE Transactions on Biomedical Engineering • 2007
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…