Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics.

  title={Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics.},
  author={Oyvind Halskau and Raul Perez-Jimenez and Beatriz Ibarra-Molero and Jarl Underhaug and V{\'i}ctor Mu{\~n}oz and Aurora Martinez and Jose M. Sanchez-Ruiz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 25},
Protein folding barriers, which range from zero to the tens of RT that result in classical two-state kinetics, are primarily determined by protein size and structural topology [Plaxco KW, Simons KT, Baker D (1998) J Mol Biol 277:985-994]. Here, we investigate the thermodynamic folding barriers of two relatively large proteins of the same size and topology: bovine alpha-lactalbumin (BLA) and hen-egg-white lysozyme (HEWL). From the analysis of differential scanning calorimetry experiments with… CONTINUE READING
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