Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

  title={Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease},
  author={M. Nalls and N. Pankratz and C. Lill and Chuong B. Do and D. Hernandez and M. Saad and A. DeStefano and E. Kara and J. Bras and M. Sharma and C. Schulte and M. Keller and Sampath Arepalli and Christopher Letson and Connor Edsall and H. Stef{\'a}nsson and X. Liu and H. Pliner and J. Lee and R. Cheng and M. Ikram and J. Ioannidis and G. Hadjigeorgiou and J. Bis and M. Mart{\'i}nez and J. Perlmutter and A. Goate and K. Marder and B. Fiske and Margaret Sutherland and G. Xiromerisiou and R. Myers and L. Clark and K. Stef{\'a}nsson and J. Hardy and P. Heutink and H. Chen and N. Wood and H. Houlden and H. Payami and A. Brice and W. Scott and T. Gasser and L. Bertram and N. Eriksson and T. Foroud and A. Singleton},
  journal={Nature genetics},
  pages={989 - 993}
  • M. Nalls, N. Pankratz, +44 authors A. Singleton
  • Published 2014
  • Biology, Medicine
  • Nature genetics
  • We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci… CONTINUE READING
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