Large-scale manufacture of peptide therapeutics by chemical synthesis

@article{Bray2003LargescaleMO,
  title={Large-scale manufacture of peptide therapeutics by chemical synthesis},
  author={Brian Bray},
  journal={Nature Reviews Drug Discovery},
  year={2003},
  volume={2},
  pages={587-593}
}
The large-scale commercial production of a 36-amino-acid peptide by chemical synthesis has been demonstrated in the development of enfuvirtide (T-20 or Fuzeon), a first-in-class membrane fusion inhibitor for the treatment of HIV. The rationale behind route selection and the scale-up of the process used to manufacture enfuvirtide are discussed.