Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

  title={Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium},
  author={Virginie J M Verhoeven and Pirro G Hysi and S. M. Saw and Veronique Vitart and A. Vajhi Mirshahi and Jeremy A Guggenheim and Mary Frances Cotch and Kenji Yamashiro and Paul N Baird and David A Mackey and Robert Wojciechowski and M. Kamran Ikram and Alex W. Hewitt and Priya Duggal and Sarayut Janmahasatian and Chiea Chuen Khor and Qiao Fan and Xin Zhou and Terri L Young and E. Shyong Tai and Liang Kee Goh and Yi-Ju Li and Tin Aung and Eranga Vithana and Yik Y. Teo and Wanting Tay and Xueling Sim and Igor Rudan and Caroline Hayward and Alan F. Wright and Ozren Pola{\vs}ek and Harry Campbell and James F Wilson and Brian Fleck and Isao Nakata and Nagahisa Yoshimura and Ryo Yamada and Fumihiko Matsuda and Kyoko Ohno-Matsui and Abhishek Nag and George Mcmahon and Beate St. Pourcain and Yi Lu and J S Rahi and Phillippa M. Cumberland and Shomi Shanker Bhattacharya and Claire L Simpson and Larry D. Atwood and Xiaohui Li and Leslie J. Raffel and Federico Murgia and Laura Portas and Dominiek D. G. Despriet and Leonieke M. E. van Koolwijk and Christian Wolfram and Karl J. Lackner and Anke Toenjes and Reedik M{\"a}gi and Terho Lehtim{\"a}ki and Mika A. P. K{\"a}h{\"o}nen and T{\"o}nu Esko and Andres Metspalu and Taina Rantanen and Olavi P{\"a}rssinen and Barbara E. K. Klein and Thomas Meitinger and Tim D. Spector and Ben A. Oostra and Albert Vernon Smith and Paulus T. V. M. de Jong and Albert Hofman and Najaf Amin and Lennart C. Karssen and Fernando Rivadeneira and Johannes R. Vingerling and Guðn{\'y} Eir{\'i}ksd{\'o}ttir and Vilmundur Gudnason and Angela D{\"o}ring and Thomas Bettecken and Andr{\'e} G. Uitterlinden and Cathy Williams and Tanja Zeller and Rapha{\"e}le Castagn{\'e} and Konrad Oexle and Cornelia M van Duijn and Sudha K. Iyengar and Paul Mitchell and Jie Jin Wang and Ren{\'e} H{\"o}hn and Norbert Pfeiffer and Joan E. Bailey-Wilson and Dwight E. Stambolian and T. -T. Wong and Christopher J Hammond and Caroline C. W. Klaver},
  booktitle={Human Genetics},
Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and meta-analysis study in which we assessed whether these two loci are also associated with myopia in other populations. The study population comprised 31 cohorts from the Consortium of Refractive Error and Myopia… CONTINUE READING


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