Large-scale identification of chemically induced mutations in Drosophila melanogaster.

@article{Haelterman2014LargescaleIO,
  title={Large-scale identification of chemically induced mutations in Drosophila melanogaster.},
  author={Nele A. Haelterman and Lichun Jiang and Yumei Li and Vafa Bayat and Hector Paulo Sandoval and Berrak Ugur and Kai Li Tan and Ke Zhang and Danqing Bei and Bo Xiong and Wu-Lin Charng and Theodore Busby and Adeel Jawaid and G Schmale David and Manish K Jaiswal and Koen J. T. Venken and Shinya Yamamoto and Rui Chen and Hugo J. Bellen},
  journal={Genome research},
  year={2014},
  volume={24 10},
  pages={
          1707-18
        }
}
Forward genetic screens using chemical mutagens have been successful in defining the function of thousands of genes in eukaryotic model organisms. The main drawback of this strategy is the time-consuming identification of the molecular lesions causative of the phenotypes of interest. With whole-genome sequencing (WGS), it is now possible to sequence hundreds of strains, but determining which mutations are causative among thousands of polymorphisms remains challenging. We have sequenced 394… CONTINUE READING

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