Large-scale identification of chemically induced mutations in Drosophila melanogaster.

@article{Haelterman2014LargescaleIO,
  title={Large-scale identification of chemically induced mutations in Drosophila melanogaster.},
  author={Nele A. Haelterman and Lichun Jiang and Y. Li and V. Bayat and H. Sandoval and Berrak Ugur and Kai Li Tan and K. Zhang and Danqing Bei and B. Xiong and W. Charng and Theodore Busby and Adeel Jawaid and G. David and M. Jaiswal and Koen J. T. Venken and S. Yamamoto and R. Chen and H. Bellen},
  journal={Genome research},
  year={2014},
  volume={24 10},
  pages={
          1707-18
        }
}
  • Nele A. Haelterman, Lichun Jiang, +16 authors H. Bellen
  • Published 2014
  • Biology, Medicine
  • Genome research
  • Forward genetic screens using chemical mutagens have been successful in defining the function of thousands of genes in eukaryotic model organisms. The main drawback of this strategy is the time-consuming identification of the molecular lesions causative of the phenotypes of interest. With whole-genome sequencing (WGS), it is now possible to sequence hundreds of strains, but determining which mutations are causative among thousands of polymorphisms remains challenging. We have sequenced 394… CONTINUE READING
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    References

    SHOWING 1-10 OF 49 REFERENCES
    Identification of EMS-Induced Mutations in Drosophila melanogaster by Whole-Genome Sequencing
    • 125
    • Highly Influential
    • PDF
    Mapping Drosophila mutations with molecularly defined P element insertions
    • R. Zhai, P. Hiesinger, +9 authors H. Bellen
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2003
    • 98
    • PDF
    Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
    • 755
    • Highly Influential
    • PDF
    Retention of Induced Mutations in a Drosophila Reverse-Genetic Resource
    • 38
    • Highly Influential
    • PDF
    Analysis of Multiple Ethyl Methanesulfonate-Mutagenized Caenorhabditis elegans Strains by Whole-Genome Sequencing
    • 88
    • Highly Influential
    • PDF
    A Molecularly Defined Duplication Set for the X Chromosome of Drosophila melanogaster
    • 79
    • PDF