Large-scale identification of chemically induced mutations in Drosophila melanogaster.

  title={Large-scale identification of chemically induced mutations in Drosophila melanogaster.},
  author={Nele A. Haelterman and Lichun Jiang and Y. Li and V. Bayat and H. Sandoval and Berrak Ugur and Kai Li Tan and K. Zhang and Danqing Bei and B. Xiong and W. Charng and Theodore Busby and Adeel Jawaid and G. David and M. Jaiswal and Koen J. T. Venken and S. Yamamoto and R. Chen and H. Bellen},
  journal={Genome research},
  volume={24 10},
  • Nele A. Haelterman, Lichun Jiang, +16 authors H. Bellen
  • Published 2014
  • Biology, Medicine
  • Genome research
  • Forward genetic screens using chemical mutagens have been successful in defining the function of thousands of genes in eukaryotic model organisms. The main drawback of this strategy is the time-consuming identification of the molecular lesions causative of the phenotypes of interest. With whole-genome sequencing (WGS), it is now possible to sequence hundreds of strains, but determining which mutations are causative among thousands of polymorphisms remains challenging. We have sequenced 394… CONTINUE READING
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