Large-scale genotyping identifies 41 new loci associated with breast cancer risk

  title={Large-scale genotyping identifies 41 new loci associated with breast cancer risk},
  author={Kyriaki Michailidou and Per Hall and Anna Gonz{\'a}lez-Neira and Maya Ghoussaini and Joe Dennis and Roger L Milne and Marjanka K. Schmidt and Jenny Chang-Claude and Stig E Bojesen and Manjeet K. Bolla and Qin Wang and Ed Dicks and Andrew Lee and C. R. A. Turnbull and Nazneen Rahman and Olivia Fletcher and Julian Peto and Lorna Gibson and Isabel dos Santos Silva and Heli Nevanlinna and Taru A Muranen and Kristiina Aittom{\"a}ki and Carl Blomqvist and Kamila Czene and Astrid Irwanto and Jianping Liu and Quinten Waisfisz and Hanne Meijers-Heijboer and Muriel A. Adank and Rob B. van der Luijt and Rebecca Hein and Norbert Dahmen and Lars Beckman and Alfons Meindl and Rita Katharina Schmutzler and Bertram M{\"u}ller-Myhsok and Peter Lichtner and John L. Hopper and Melissa C. Southey and Enes Makalic and Daniel F. Schmidt and Andr{\'e} G. Uitterlinden and Albert Hofman and David J. Hunter and Stephen J. Chanock and Daniel D Vincent and François Bacot and Daniel C. Tessier and Sander Canisius and Lodewyk F. A. Wessels and Christopher A. Haiman and Mitul H. Shah and Robert L Luben and Judith K Brown and Craig Luccarini and Nils Schoof and Keith N Humphreys and Jingmei Li and B\orge G. Nordestgaard and Sune Fallgaard Nielsen and Henrik Flyger and Fergus J. Couch and Xianshu Wang and Celine M. Vachon and Kristen Stevens and Diether Lambrechts and Matthieu Moisse and Robert J. Paridaens and M. -R. Christiaens and Anja Rudolph and Stefan Nickels and Dieter Flesch-Janys and Nichola Johnson and Zoe Aitken and Kirsimari Aaltonen and Tuomas Heikkinen and Annegien Broeks and Laura J. van't Veer and C. Ellen van der Schoot and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Pierre Laurent-Puig and Florence Menegaux and Frederik Marm{\'e} and Andreas Schneeweiss and Christof Sohn and Barbara Burwinkel and Mar{\'i}a Pilar Zamora and Jos{\'e} Ignacio Arias P{\'e}rez and Guillermo Pita and Maria Del Rosario Zariategui de Alonso and Angela Cox and Ian Wallace Brock and Simon S. Cross and Malcolm W. R. Reed and Elinor J. Sawyer and Ian Tomlinson and Michael John Kerin and Nicola M Miller and Brian E. Henderson and Fredrick Schumacher and Loic Le Marchand and Irene L Andrulis and J. A. G. Knight and Gordon Glendon and Anna Marie Mulligan and A. Arto Lindblom and Sara Margolin and Maartje J. Hooning and Antoinette Hollestelle and Ans M. W. van den Ouweland and Agnes Jager and Quang Minh Bui and Jennifer Stone and Gillian S. Dite and Carmel Apicella and Helen Tsimiklis and Graham G. Giles and Gianluca Severi and Laura Baglietto and Peter A. Fasching and Lothar Haeberle and Arif B. Ekici and Matthias W. Beckmann and Hermann Brenner and Heiko Mueller and Volker Arndt and Christa Stegmaier and Anthony J Swerdlow and Alan Ashworth and Nick Orr and Michael Jones and Jonine D Figueroa and Jolanta Lissowska and Louise Anette Brinton and Mark S. Goldberg and France Labr{\`e}che and Martine Dumont and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Hiltrud Brauch and Ute Hamann and Thomas Br{\"u}ning and Paolo Radice and Paolo Peterlongo and Siranoush Manoukian and Bernardo Bonanni and Peter Devilee and Rob A. E. M. Tollenaar and Caroline M. Seynaeve and Christi J. van Asperen and Anna Jakubowska and Jan A. Lubiński and Katarzyna Jaworska and Katarzyna Durda and Arto J Mannermaa and Vesa V. Kataja and Veli-Matti Kosma and Jaana M. Hartikainen and Natalia Valerijevna Bogdanova and Natalia N. Antonenkova and Thilo D{\"o}rk and Vessela N. Kristensen and Hoda Anton-Culver and Susan L. Slager and Amanda Ewart Toland and Stephen Edge and Florentia Fostira and Daehee Kang and Keun-young Yoo and Dong-Young Noh and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Aiko Sueta and Anna H Wu and Chiu-chen Tseng and David J. Van Den Berg and Daniel O. Stram and Xiao-ou Shu and Wei Lu and Yu-tang Gao and Hui Cai and Soo Hwang Teo and Cheng-Har Yip and Sze Yee Phuah and Belinda K. Cornes and M. Hartman and Hui Miao and Wei-yen Lim and Jen-Hwei Sng and Kenneth Ross Muir and Artitaya Lophatananon and Sarah Lynette Stewart-Brown and Pornthep Siriwanarangsan and Chen-yang Shen and C Hsiung and P Wu and Shian-ling Ding and Suleeporn Sangrajrang and Val{\'e}rie Gaborieau and Paul Brennan and James Mckay and William J. Blot and Lisa Beth Signorello and Qiuyin Cai and Wei Zheng and Sandra L Deming-Halverson and Martha J Shrubsole and Jirong Long and Jacques Simard and Montserrat Garc{\'i}a-Closas and Paul D. P. Pharoah and Georgia Chenevix-Trench and Alison M. Dunning and Javier Ben{\'i}tez and Douglas F. Easton},
  journal={Nature Genetics},
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European… CONTINUE READING
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