Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

@article{Sklar2011LargescaleGA,
  title={Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4},
  author={Pamela Sklar and Stephan Ripke and Laura J. Scott and Ole Andreas Andreassen and Sven Cichon and Nicholas John Craddock and Howard J. Edenberg and Jr. John Nurnberger and Marcella Rietschel and Douglas H. R. Blackwood and Aiden Corvin and Matthew Flickinger and Weihua Guan and Morten Mattingsdal and Andrew McQuillin and Phoenix Kwan and Thomas F. Wienker and Mark J. Daly and Frank Dudbridge and Peter Holmans and Danyu Lin and Margit Burmeister and Tiffany A. Greenwood and Marian Lindsay Hamshere and Pierandrea Muglia and Erin N Smith and Peter P. Zandi and Caroline M Nievergelt and Rebecca Mckinney and Paul D. Shilling and Nicholas J. Schork and Cinnamon S. Bloss and Tatiana Foroud and Daniel L. Koller and Elliot S. Gershon and Chunyu Liu and Judith A. Badner and William A. Scheftner and William Lawson and Evaristus A. Nwulia and Mar{\'i}a R{\'i}os Hip{\'o}lito and William Coryell and John P. Rice and William Byerley and Francis J. McMahon and Thomas G. Schulze and Wade. H. Berrettini and Falk W. Lohoff and James B. Potash and Pamela B. Mahon and Melvin G. McInnis and Sebastian Z{\"o}llner and Peng Zhang and David Wesley Craig and Szabocls Szelinger and Thomas Boone Barrett and Ren{\'e} Breuer and Sandra Meier and Jana Strohmaier and Stephanie H. Witt and Federica Tozzi and Anne Farmer and Peter McGuffin and John Strauss and Wei Min Xu and James L Kennedy and John B Vincent and Keith A. Matthews and Richard O Day and Manuel A. R. Ferreira and Colm {\'O}'D{\'u}shl{\'a}ine and Roy H. Perlis and Soumya Raychaudhuri and Douglas M. Ruderfer and Phil H. Lee and Jordan W. Smoller and Jun Li and Devin Absher and William E. Bunney and Jack David Barchas and Alan F. Schatzberg and Edward Gardner Jones and Fan Guo Meng and R. Campbell Thompson and Stanley J. Watson and Richard M. Myers and Huda Akil and Michael Boehnke and Kim Chambert and Jennifer L. Moran and Edward M. Scolnick and Srdjan Djurovic and Ingrid Melle and Gunnar Morken and Michael Gill and Derek W. Morris and Emma Quinn and Thomas W. M{\"u}hleisen and Franziska Degenhardt and Manuel Mattheisen and Johannes Schumacher and Wolfgang Nattheim De Maier and Michael Steffens and P. Propping and Markus M. N{\"o}then and Adebayo Anjorin and Nick J Bass and Hugh M.D. Gurling and Radhika Kandaswamy and Jacob Lawrence and Kevin Mcghee and Andrew M. McIntosh and Alan W. Mclean and Walter J. Muir and Ben S. Pickard and Gerome Breen and David M. St Clair and S Julius Caesar and Katherine Gordon-Smith and Lisa Kimes Jones and Christine Marion Fraser and Elaine K Green and Detelina Grozeva and Ian Richard Jones and George Kirov and V. Moskvina and Ivan Nikolov and Michael C. O'Donovan and Michael J Owen and David A. Collier and Amanda Elkin and Richard Williamson and Allan H Young and Ian Nicol Ferrier and K{\'a}ri Stef{\'a}nsson and Hreinn Stef{\'a}nsson and Porgeir Porgeirsson and Stacy Steinberg and {\'O}mar G{\'u}stafsson and Sarah E Bergen and Vishwajit Nimgaonkar and Christina M. Hultman and Mikael Land{\'e}n and Paul Lichtenstein and Patrick F. Sullivan and Martin Schalling and Urban {\"O}sby and L Magnus Backlund and Louise Fris{\'e}n and Niklas L{\aa}ngstr{\"o}m and St{\'e}phane Jamain and Marion Leboyer and Bruno Etain and Frank Bellivier and Hannes Petursson and Engilbert Sigurdsson and Bertram M{\"u}ller-Mysok and Susanne Lucae and Markus J. Schwarz and Janice M Fullerton and Peter R. Schofield and Nicholas G. Martin and Grant W. Montgomery and Mark C. Lathrop and Hogni Oskarsson and Michael Bauer and Adam Clayton Wright and Philip B. Mitchell and Martin Hautzinger and Andreas Reif and John R Kelsoe and Shaun M Purcell},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={977-983}
}
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P < 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 × 10−7). An analysis of all 11,974 bipolar disorder cases and 51,792 controls… CONTINUE READING
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