Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.

@article{Aigner2006LargescaleGE,
  title={Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.},
  author={Thomas Aigner and Katrin Fundel and Joachim Saas and Pia Margarethe Gebhard and J. Friedrich Haag and Tilo Weiss and Alexander Zien and Franz Obermayr and Ralf Zimmer and Eckart Bartnik},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 11},
  pages={
          3533-44
        }
}
OBJECTIVE Despite many research efforts in recent decades, the major pathogenetic mechanisms of osteoarthritis (OA), including gene alterations occurring during OA cartilage degeneration, are poorly understood, and there is no disease-modifying treatment approach. The present study was therefore initiated in order to identify differentially expressed disease-related genes and potential therapeutic targets. METHODS This investigation consisted of a large gene expression profiling study… CONTINUE READING
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