Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

  title={Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.},
  author={Richa Saxena and Clara C. Elbers and Yiran Guo and Inga Peter and Tom R. Gaunt and Jessica L. Mega and Matthew B. Lanktree and Archana Tare and Berta Almoguera Castillo and Yun Rose Li and Toby Johnson and Marcel Bruinenberg and Diane Gilbert-Diamond and Ramakrishnan Rajagopalan and Benjamin F. Voight and Ashok Balasubramanyam and John Barnard and Florianne Bauer and Jens Baumert and Tushar Bhangale and B O Boehm and Peter S. Braund and Paul R. Burton and Hareesh R. Chandrupatla and Robert Clarke and Rhonda M. Cooper-Dehoff and Errol D. Crook and George Davey-Smith and I. N. Day and Anthonius de Boer and Mark C H de Groot and Fotios Drenos and Jane Ferguson and Caroline Fox and Clement E. Furlong and Quince D. Gibson and Christian Gieger and Lisa A Gilhuijs-Pederson and Joseph T. Glessner and Anuj Goel and Yan Gong and Struan F. A. Grant and Diederick E. Grobbee and Claire Hastie and Steve E Humphries and Cecilia Kim and Mika Kivimaki and Marcus Kleber and Christa Meisinger and Meena Kumari and Taimour Y Langaee and Debbie A Lawlor and Mingyao Li and Maximilian T. Lobmeyer and Anke-Hilse Maitland-van der Zee and M. F. L. Meijs and Cliona Molony and David A. Morrow and Gurunathan Murugesan and Solomon K. Musani and Christopher P. Nelson and Stephen Newhouse and Jeffrey R. O'Connell and Sandosh Padmanabhan and Jutta A Palmen and Sanjey R Patel and Carl J Pepine and Mary B Pettinger and Thomas S. Price and Suzanne E Rafelt and J. Ranchalis and Asif Rasheed and E. Rosenthal and Ingo Ruczinski and Sonia Shah and Haiqing Shen and Guenther Silbernagel and Erin N. Smith and Annemieke M. W. Spijkerman and Alice Stanton and Michael W. Steffes and Barbara Thorand and Mieke D. Trip and Pim van der Harst and A DaphneL.vander and Erik P. A. van Iperen and Jessica van Setten and Jana V van Vliet-Ostaptchouk and Niek Verweij and Bruce H. R. Wolffenbuttel and T Young and Mohammad Hadi Zafarmand and Joseph M. Zmuda and Michael Boehnke and David Altshuler and Mark Mccarthy and W. H. Linda Kao and James S. Pankow and Thomas P. Cappola and Peter Sever and Neil Poulter and Mark Caulfield and A Dominiczak and Denis C. Shields and Deepak L Bhatt and Li Zhang and Sean P. Curtis and John Danesh and Juan P. Casas and Yvonne T van der Schouw and N. Charlotte Onland-Moret and Pieter Adrianus Doevendans and Gerald W. Dorn and Martin Farrall and Garret A. FitzGerald and Anders Hamsten and Robert Hegele and Aroon D. Hingorani and Marten H. Hofker and Gordon S. Huggins and Thomas Illig and Gail P. Jarvik and Julie A. Johnson and Olaf H Klungel and William C. Knowler and Wolfgang Koenig and Winfried Maerz and James B. Meigs and Olle Melander and Patricia B. Munroe and Braxton D. Mitchell and Susan J Bielinski and Daniel J. Rader and Muredach P. Reilly and Stephen S. Rich and Jerome I. Rotter and Danish Saleheen and Nilesh J. Samani and Eric E. Schadt and Alan R. Shuldiner and Roy Silverstein and Kandice K. Kottke-Marchant and Philippa J. Talmud and Hugh Watkins and Folkert W. Asselbergs and Paul I W de Bakker and Jeanne McCaffery and Cisca Wijmenga and Marc S. Sabatine and James G. Wilson and Alex P. Reiner and Donald W. Bowden and Hakon Hakonarson and David S Siscovick and Brendan J. Keating},
  journal={American journal of human genetics},
  volume={90 3},
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies comprising 14,073 cases and 57,489 controls of European descent confirmed eight established T2D loci at genome-wide… CONTINUE READING
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