Large-scale field trial of Ty21a live oral typhoid vaccine in enteric-coated capsule formulation.

@article{Levine1987LargescaleFT,
  title={Large-scale field trial of Ty21a live oral typhoid vaccine in enteric-coated capsule formulation.},
  author={Myron M. Levine and Catterine Ferreccio and Richard E. Black and R. Germanier},
  journal={Lancet},
  year={1987},
  volume={1 8541},
  pages={1049-52}
}
Three doses, given within one week, of Ty21a attenuated Salmonella typhi oral vaccine in an enteric-coated formulation provided 67% efficacy for at least 3 years in a randomised, placebo-controlled field trial involving 109,000 schoolchildren in Santiago, Chile. Increasing the interval between doses to twenty-one days did not enhance protection. Significantly less protection followed administration of vaccine in gelatin capsules with sodium bicarbonate. Ty21a provides the same level of… CONTINUE READING

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