Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae.

@article{Frster2003LargescaleEO,
  title={Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae.},
  author={Jochen F{\"o}rster and Iman Famili and Bernhard O. Palsson and Jens Nielsen},
  journal={Omics : a journal of integrative biology},
  year={2003},
  volume={7 2},
  pages={
          193-202
        }
}
A large-scale in silico evaluation of gene deletions in Saccharomyces cerevisiae was conducted using a genome-scale reconstructed metabolic model. The effect of 599 single gene deletions on cell viability was simulated in silico and compared to published experimental results. In 526 cases (87.8%), the in silico results were in agreement with experimental observations when growth on synthetic complete medium was simulated. Viable phenotypes were correctly predicted in 89.4% (496 out of 555) and… CONTINUE READING

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