Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.

@article{Roemer2003LargescaleEG,
  title={Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.},
  author={T. Roemer and B. Jiang and J. Davison and T. Ketela and Karynn Veillette and A. Breton and Fatou Tandia and Annie Linteau and S. Sillaots and Catarina Marta and Nick Martel and S. V{\'e}ronneau and S. Lemieux and S. Kauffman and J. Becker and R. Storms and Charles Boone and H. Bussey},
  journal={Molecular microbiology},
  year={2003},
  volume={50 1},
  pages={
          167-81
        }
}
  • T. Roemer, B. Jiang, +15 authors H. Bussey
  • Published 2003
  • Medicine, Biology
  • Molecular microbiology
  • Candida albicans is the primary fungal pathogen of humans. Despite the need for novel drugs to combat fungal infections [Sobel, J.D. (2000) Clin Infectious Dis 30: 652], antifungal drug discovery is currently limited by both the availability of suitable drug targets and assays to screen corresponding targets. A functional genomics approach based on the diploid C. albicans genome sequence, termed GRACETM (gene replacement and conditional expression), was used to assess gene essentiality through… CONTINUE READING
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