Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro

@article{Belmont1989LargescaleCS,
  title={Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro},
  author={Andrew S Belmont and Michael B. Braunfeld and John Sedat and David A. Agard},
  journal={Chromosoma},
  year={1989},
  volume={98},
  pages={129-143}
}
Higher-order chromatin structural domains approximately 130 nm in width are observed as prominent components of both Drosophila melanogaster and human mitotic chromosomes using buffer conditions which preserve chromosome morphology as determined by light microscopic comparison with chromosomes within living cells. Spatially discrete chromatin structural domains of similar size also exist as prominent components within interphase nuclei prepared under equivalent conditions. Examination of… CONTINUE READING
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