Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.

@article{McCarthy2004LargeSA,
  title={Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.},
  author={Jeanette McCarthy and Alex N. Parker and Rany Salem and David J Moliterno and Qi Wang and Edward F Plow and Sudha Rao and G Shen and Wendy J. Rogers and Laura Kristin Newby and Roberto Cannata and Kathleen Glatt and Eric J. Topol},
  journal={Journal of medical genetics},
  year={2004},
  volume={41 5},
  pages={334-41}
}
BACKGROUND to date, only three groups have reported data from large scale genetic association studies of coronary heart disease using a case control design. METHODS AND RESULTS to extend our initial report of 62 genes, we present data for 210 polymorphisms in 111 candidate genes genotyped in 352 white subjects with familial, premature coronary heart disease (onset age for men, 45; for women, 50) and a random sample of 418 population based whites. Multivariate logistic regression analysis was… CONTINUE READING

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